Potential Protective Effect of Fortified Camel Milk Products with Chromium on Alloxan Induced Hyperglycemia in Rats

Oxidative stress and dyslipidemia enhancement are associated with diabetes mellitus (DM). Camel milk (CM), Yogurt-Camel milk (YCM) and Probiotic–Camel milk (PCM) alone or in supplementation with other drug are gaining increasing recognition due to their beneficial effects in prevention many health problems. This study was designed to investigate the protective effect of CM, YCM and PCM alone or in combination with chromium picolinate (CM-CrPi, YCM-CrPi and PCM-CrPi) on alloxan-induced diabetic rats. Animals were randomly divided into eight groups: Group I served as normal control, while animals of group 2 were rendered to diabetes by alloxan injection (150 mg/kg bw, i.p), meanwhile groups 3-8 fed daily with CM products by oral gavage (2 ml/rat) for 8 weeks then diabetes was induced by alloxan injection. CM, YCM and PCM pre-treatment reduced (p < 0.05) glycaemia, HbA1C with improved lipids profile, lipid peroxidation, total antioxidant capacity and elevated serum insulin in diabetic rats. A histopathological examination of pancreases tissue was observed. Camel's milk products supplemented with CrPi has potential ameliorated effect in diabetic rats and can protect against hyperglycemia with improve lipid pattern, antioxidant activity and healthy status of diabetic rats